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Submitted: 22 Sep 2017
Accepted: 01 Nov 2017
First published online: 30 Dec 2017

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Pharm Sci. 2017;23(4):330-334 doi: 10.15171/PS.2017.48

Modelling the Preferential Solvation of Ferulic Acid in {2-Propanol (1) + Water (2)} Mixtures at 298.15 K

Short Communication

Abolghasem Jouyban 1,2, Fleming Martínez 3 *

1 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia –Sede Bogotá, Cra. 30 No. 45-03, Bogotá D.C., Colombia.

Background: Recently Haq et al. reported the equilibrium solubility in {2-propanol (1) + water (2)} mixtures at several temperatures with some numerical correlation analysis. Nevertheless, no attempt was made to evaluate the preferential solvation of this compound by the solvents. Methods: Preferential solvation of ferulic acid in the saturated mixtures at 298.15 K was analyzed based on the inverse Kirkwood-Buff integrals as described in the literature. Results: Ferulic acid is preferentially solvated by water in water-rich mixtures (0.00 < x1 < 0.19) but preferentially solvated by 2-propanol in mixtures with composition 0.19 < x1 < 1.00. Conclusion: These results could be interpreted as a consequence of hydrophobic hydration around the non-polar groups of the solute in the former case (0.00 < x1 < 0.19). Moreover, in the last case (0.19 < x1 < 1.00), the observed trend could be a consequence of the acid behavior of ferulic acid in front to 2-propanol molecules because this cosolvent is more basic than water as described by the respective solvatochromic parameters.

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