Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  

ISSN: 1735-403X      eISSN: 2383-2886  
Export citation
Reference Manager

Cite by
Google Scholar

Article History
Submitted: 18 Jun 2017
Accepted: 01 Nov 2017
First published online: 30 Dec 2017

Article Access Statistics
Abstract Page Views: 311
PDF Downloads: 571
Full Text Views: 0

Pharm Sci. 2017;23(4):285-292 doi: 10.15171/PS.2017.42

Physical Characteristics of Liposomal Formulation Dispersed in HPMC Matrix and Freeze-Dried Using Maltodextrin and Mannitol as Lyoprotectant 

Research Article

Raditya Weka Nugraheni 1, Dwi Setyawan 1, Helmy Yusuf 1 *

1 Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga. Surabaya, Indonesia

Background: The present study aims to design formulation of liposomes that are well-preserved during freeze-drying. The combination of Hydroxy Propyl Methyl Cellulose (HPMC) as dispersion matrix and lyoprotectants; maltodextrin or mannitol, was employed to prevent aggregation and/or recrystallization. The obtained dry products were investigated in terms of their physical characteristics. Methods: Liposomes were prepared using thin film method and hydrated with the lyoprotectant solution. The formed liposomes were mixed with HPMC gel and freeze-dried. The obtained solid products were characterized using Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), and Scanning Electron Microscopy (SEM). Results: The DSC thermograms of formulations with maltodextrin were relatively homogenous, yet exhibiting meta-stable properties. In contrast, the formulations using mannitol showed phase separation. These results were confirmed by XRD data, in which formulations with maltodextrin showed no intensive peaks, indicating amorphous solid while the formulations with mannitol exhibited more intensive peaks, indicating the presence of crystalline solids. The SEM images of both maltodextrin and mannitol-containing formulations showed porous matrix with spherical liposomes trapped in the matrices. The SEM images also correspond to the DSC and XRD data, where crystalline solid existed in the mannitol-containing formula. Conclusion: The developed liposomes formulation using combination of HPMC matrix and maltodextrin showed potential in preserving liposomes structure, contrary to those of using mannitol.

First name  
Last name  
Email address  
Security code

This Article

Google Scholar
Articles by Nugraheni RW
Articles by Setyawan D
Articles by Yusuf H

Articles by Nugraheni RW
Articles by Setyawan D
Articles by Yusuf H

Share this article!
© 2016 Tabriz University of Medical Sciences; unless otherwise stated
Press Manuscript Online. Powered by MAADRAYAN