Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  

ISSN: 1735-403X      eISSN: 2383-2886  
Export citation
Reference Manager

Cite by
Google Scholar

Article History
Submitted: 15 Oct 2016
Accepted: 29 Dec 2016

Article Access Statistics
Abstract Page Views: 331
PDF Downloads: 357
Full Text Views: 0

Pharm Sci. 2017;23(1):77-81 doi: 10.15171/PS.2017.12

An In Vitro Aerosolization Efficiency Comparison of Generic and Branded Salbutamol Metered Dose Inhalers

Short Communication

Sara Rahimkhani 1, Saeed Ghanbarzadeh 2, Ali Nokhodchi 3,4, Hamed Hamishehkar 5 *

1 Biotechnology Research Center and School of Pharmacy, International Branch-Aras, Tabriz University of Medical Science, Tabriz, Iran
2 Zanjan Pharmaceutical Nanotechnology Research Center, and Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
3 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran
4 School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
5 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Background: Due to the high rate of pulmonary diseases, respiratory drug delivery systems have been attracted excessive attention for the past decades. Because of limitations and growing drug bill, physicians are encouraged to prescribe generically whenever possible. The purpose of this study was to evaluate whether there was any significant difference in aerosolization performance between a reference brand Salbutamol (A) Metered Dose Inhalers (MDIs) and two generic products (B and C). Methods: The aerosolization performance of MDIs was evaluated by calculating aerosolization indexes including fine particle fraction (FPF), fine particle dose (FPD), geometric standard deviation (GSD) and mass median aerodynamic diameters (MMAD) by using the next generation impactor. Results: Although aerosolization indexes of MDI A were superior than the Iranian brands, but the differences were not statistically significant. Conclusion: These results verified that generic MDIs deliver similar quantities of Salbutamol to the reference brand and aerosolization performance parameters of generic Salbutamol MDIs did not differ significantly from the reference brand.

First name  
Last name  
Email address  
Security code

This Article

Google Scholar
Articles by Rahimkhani S
Articles by Ghanbarzadeh S
Articles by Nokhodchi A
Articles by Hamishehkar H

Articles by Rahimkhani S
Articles by Ghanbarzadeh S
Articles by Nokhodchi A
Articles by Hamishehkar H

Share this article!
© 2016 Tabriz University of Medical Sciences; unless otherwise stated
Press Manuscript Online. Powered by MAADRAYAN