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Article History
Submitted: 13 Sep 2015
Accepted: 12 Dec 2015
First published online: 30 Mar 2016

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Pharm Sci. 2016;22(1):22-27 doi: 10.15171/PS.2016.05

Combination of Solvent Displacement and Wet Ball Milling Techniques for Size Reduction of Celecoxib

Research Article

Shadi Yaqoubi 1, Mohammad Barzegar Jalali 2, Khosro Adibkia 2, Hamed Hamishehkar 3 *

1 Biotechnology Research Center and Students’ Research Co mmittee, Tabriz University of Medical Sciences, Tabriz, Iran
2 Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran



Abstract
Background: The objective of the present study was to investigate the combinative effect of ball milling and solvent displacement method on size reduction of Celecoxib particles. Celecoxib is a poorly water soluble cyclooxygenase 2 inhibitor which has a wide range of therapeutic applicability. Methods: Microparticles were developed via solvent displacement method followed by planetary ball milling. In order to obtain an optimized size and size distribution of Celecoxib microparticles various factors were evaluated; the role of solvent type, type and concentration of stabilizer, milling effect, and the effect of milling duration were the most important factors studied during the present investigation. Results: All the obtained formulations were in micron range that the smallest particles had the size of 1.76 μm and the formulation containing the largest particles was of 8.30 μm by volume mean diameter. Both solvent displacement and milling methods are common and potential approaches in order to formulate micron scaled particles. Conclusion: The combination of these two methods generates a synergistic effect which leads to smaller particle size and a narrow size distribution. Celecoxib microparticles have the potential to use as promising delivery systems to treat various disease and malignancies.





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