Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  

ISSN: 1735-403X      eISSN: 2383-2886  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar



Article History
Submitted: 01 Jun 2015

Article Access Statistics
Abstract Page Views: 481
PDF Downloads: 513
Full Text Views: 0

Pharm Sci. 2015;21(3):145-151 doi: 10.15171/PS.2015.29

Preparation and Characterization of Rutin-loaded Nanophytosomes

Original Research

Zahra Hooresfand 1, Saeed Ghanbarzadeh 2, Hamed Hamishehkar 3 *

1 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran



Abstract
Background: Plant-derived materials are increasingly gaining attention as dietary supplements and due to their role in medicinal application. Rutin, a phenolic antioxidant, is a member of bioflavonoids which has been demonstrated to scavenge superoxide radicals and is believed to be a vital nourishing supplement due to its ability to strengthen and modulation of the permeability of the blood vessels walls. However, Rutin shows poor absorption when administered orally and its bioavailability is an important restrictive factor. Purpose: The present study was aimed to prepare and characterize a stable Rutin-loaded nanophytosomal formulation to improve its antioxidant property and bioavailability. Methods: Rutin-loaded nanophytosomes were prepared by phosphatidylcholine (PC) and cholesterol by thin layer hydration method. The physicochemical properties of prepared nanophytosomes were evaluated using particle size analyses, Furrier transformation infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Stability of the prepared nanophytosomes was also investigated during three weeks of storage period. Results: Results showed that formulation with the Rutin: PC molar ratio of 1:2 possess lowest particle size and the incorporation of cholesterol improved the physical stability of nanophytosome for over three weeks. FTIR and DSC analysis showed the formation of Rutin-phospholipid complex during the formulation development process. Conclusion: Results of the present study showed that nanophytosome can be introduced as a useful carrier for fortifying herbal medicinal compounds for application the formulation of various food and pharmaceutical products.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Hooresfand Z
Articles by Ghanbarzadeh S
Articles by Hamishehkar H

PubMed
Articles by Hooresfand Z
Articles by Ghanbarzadeh S
Articles by Hamishehkar H



Share this article!
© 2016 Tabriz University of Medical Sciences; unless otherwise stated
Press Manuscript Online. Powered by MAADRAYAN