Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  

ISSN: 1735-403X      eISSN: 2383-2886  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar



Article History
Submitted: 28 Jul 2016
Accepted: 09 Feb 2017

Article Access Statistics
Abstract Page Views: 153
PDF Downloads: 348
Full Text Views: 0

Pharm Sci. 2017;23(2):84-94 doi: 10.15171/PS.2017.14

Natural Polysaccharide based Nanoparticles for Drug/Gene Deliv­ery

Review

Sara Salatin 1,2 * , Mitra Jelvehgari 1,3

1 Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract
The dawn of the state-of-the-art methods of drug/gene delivery, nano-based delivery systems for delivery of pharmaceutically active agents into the target sites in the body have been developed. Among these, a concerted effort has been directed towards the development of biodegradable/biocompatible nanomaterials with the high potential benefits of passive/active targeting and reduced undesirable side effects. Since polysaccharides offer a large number of available reactive groups, specific targeting could be obtained by the surface coating of nanoparticles with targeting ligands. On the other hand, mucoadhesive properties of polysaccharides can be used for prolonging the residence time of delivery systems at the site of absorption. This study reviews a number of important polysaccharides with a perspective on the challenges, advantages, and disadvantages of their applications as drug/gene delivery systems.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Salatin S
Articles by Jelvehgari M

PubMed
Articles by Salatin S
Articles by Jelvehgari M



Share this article!
© 2016 Tabriz University of Medical Sciences; unless otherwise stated
Press Manuscript Online. Powered by MAADRAYAN