Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  

ISSN: 1735-403X      eISSN: 2383-2886  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar



Article History
Submitted: 21 Dec 2017
Revised: 28 Jan 2018
Accepted: 20 Mar 2018
First published online: 20 Jun 2018

Article Access Statistics
Abstract Page Views: 64
PDF Downloads: 196
Full Text Views: 0

Pharm Sci. 2018;24(2):163-167 doi: 10.15171/PS.2018.24

Solubility and Apparent Specific Volume of Sucrose in Some Aqueous Polyethylene Glycol Mixtures at 298.2 K

Short Communication

Dario A Tinjaca 1, Maria M Muñoz 1, Elaheh Rahimpour 2, Abolghasem Jouyban 2,3, Fleming Martinez 1 * , William E Acree Jr 4

1 Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia -Sede Bogotá, Cra. 30 No. 45-03, Bogotá, D.C., Colombia.
2 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Chemistry, University of North Texas, Denton, TX 76203-5070, USA.



Abstract
Background: Sucrose is the most widely used sweetener in food and pharmaceuticals. Quantitative solubility values of this excipient in aqueous polyethylene glycol (PEG) mixtures is not abundant. Thus, the main objective of this research was to determine and correlate the equilibrium solubility of sucrose in {PEG 200 (or 400) + water} mixtures at 298.2 K. Methods: Shaken flask method was used to determine isothermal solubility. Concentration measurements were performed by means of density determinations. Jouyban-Acree model was used to correlate both solubility sets. Results: Solubility of sucrose decreases non-linearly with the addition of either PEG200 or PEG400 to water. Jouyban-Acree model correlates solubility values with mixtures composition for both cosolvent systems. Moreover, apparent specific volume of sucrose were also calculated from density and compositions. Conclusion: Useful solubility values of sucrose at equilibrium in aqueous mixtures of PEG200 and PEG400, as well as their volumetric contributions to saturated solutions are reported.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Tinjaca DA
Articles by Muñoz MM
Articles by Rahimpour E
Articles by Jouyban A
Articles by Martinez F
Articles by Acree Jr WE

PubMed
Articles by Tinjaca DA
Articles by Muñoz MM
Articles by Rahimpour E
Articles by Jouyban A
Articles by Martinez F
Articles by Acree Jr WE



Share this article!
© 2016 Tabriz University of Medical Sciences; unless otherwise stated
Press Manuscript Online. Powered by MAADRAYAN