Logo-ps
Pharm Sci. 2016;22(3): 181-185.
doi: 10.15171/PS.2016.28

Scopus ID: 84989881866
  Abstract View: 1712
  PDF Download: 881

Research Article

The Effect of Nanohydrogel Oral Insulin Therapy on Serum Glucose and Insulin Level in Patients with Type 2 Diabetes: A Pilot Study

Vali Ahmadi 1, Jalil Karnoosh-Yamchi 2, Akbar Aliasgharzadeh 1, Alireza Ostad-Rahimi 2, Zeinab Nikniaz 3, Roya Salehi 1, Majid Mobasseri 1*

1 Endocrinology research center, Tabriz University of medical sciences, Tabriz-Iran
2 Nutrition research center, Tabriz University of medical sciences, Tabriz-Iran
3 Liver and gastrointestinal disease research center, Tabriz University of medical sciences, Tabriz-Iran
*Corresponding Author: Email: mobasserimajid@yahoo.com

Abstract

Background: This pilot study was designed to investigate the effect of orally delivered nanohydrogel insulin on serum glucose and insulin levels in patients with type 2 diabetes (T2DM). Methods: In this pilot before-after study, 8 T2DM patients received 300 IU insulin loaded nanohydrogel orally and the serum concentration of glucose and insulin were measured before treatment and consecutively during treatment. The area under the curve (AUC) was calculated for serum glucose and insulin and repeated measures of ANOVA, paired t-test were used for statistical analysis. Results: The changes in serum glucose level was not significant pretreatment (p=0.10) and during oral insulin treatment (p=0.71). Compared with pretreatment value, the serum glucose level was significantly lower in 7 A.M. (immediately after insulin therapy) and 8.30 A.M. during oral insulin treatment. The maximum reduction was observed 1.5 hours after insulin therapy and its effect lasted for more than 6 hours. The mean AUC of glucose was insignificantly decreased (p=0.16). The pretreatment (p=0.10) and during treatment (p=0.30) changes in serum insulin level were not statistically significant. The serum insulin level was increased significantly immediately after oral insulin therapy compared with pretreatment values. The mean AUC of insulin increased marginally significant (p=0.056). Conclusion: The results of the present pilot study showed that 300IU nanohydrogel oral insulin was effective in rapid lowering of serum glucose and its glucose lowering effect lasting for more than 6 hours. However, for any precise conclusions further studies with longer duration are needed.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1713

Your browser does not support the canvas element.


PDF Download: 881

Your browser does not support the canvas element.

Submitted: 01 Jun 2016
Accepted: 02 Jul 2016
ePublished: 30 Sep 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)