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Article History
Submitted: 09 Jun 2016
Revised: 19 Oct 2016
Accepted: 20 Oct 2016
First published online: 27 Oct 2016

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Pharm Sci. 2016;22(4):234-243 doi: 10.15171/PS.2016.37

Preparation and Physicochemical Characterization of Biodegradable mPEG-PCL Core-Shell Micelles for Delivery of Artemisinin

Research Article

Hamid Reza Kheiri Manjili 1, Hojjat Malvandi 3, Mir-Sajjad Mosavi 1, Hossein Danafar 2,3 *

1 Pharmaceutical Nanotechnology Department, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
2 Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
3 Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.



Abstract
Background: Artemisinin is a sesquiterpene lactone chemical extract from Artemisia annua, is poorly resolvable in water and a fast-acting blood active in treating the acute attack of malaria. Methods: Artemisinin was encapsulated within mPEG-PCL micelles with a single-step nano-precipitation method, leading to formation of ART/ mPEG-PCL micelles. mPEG-PCL copolymers was characterized in vitro by HNMR, FTIR and DSC techniques. Copolymers with artemisinin were self-assembled into micelles in aqueous solution. The consequential micelles were further characterized by various techniques such as DLS and AFM. Results: The results exhibited the successful formation of spherical artemisinin-loaded micelles. The artemisinin-loaded micelles showed high loading efficiency. The encapsulation efficiency of artemisinin was 63±2.31%. In vitro release of artemisinin from artemisinin-entrapped micelles followed remarkably sustained release profile. Conclusion: The results indicated that the successful formulation of artemisinin loaded mPEG-PCL micelles can improve the drug delivery of artemisinin. The results showed that nanomicelles can be promising drug delivery systems for sustaining release of artemisinin.





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Articles by Kheiri Manjili HR
Articles by Malvandi H
Articles by Mosavi M
Articles by Danafar H

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Articles by Kheiri Manjili HR
Articles by Malvandi H
Articles by Mosavi M
Articles by Danafar H



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