Pharm Sci. 2017;23(1):37-41 doi: 10.15171/PS.2017.06
Measurement and Comparison of
Inpatient Antibiotic Use in Five Different Hospitals in Tabriz
Background: There is a relation
between amounts of antibiotic uses and creation of resistant bacteria. Due to
the critical role of antibiotics and increasing trend of resistance in
developing countries, comprehensive methods of antibiotic use is necessary to
limit the threat of resistant microorganisms. In this study we compare
antibiotics consumption by Defined Daily Dose (DDD) per 100 bed-days in
teaching and private hospitals during six months in Tabriz, Iran.
Methods: Four university
hospitals and one private hospital were included in this study. Amount of their
antibiotic consumption obtained from the hospital pharmacies. Anatomical
Therapeutic Chemical (ATC) code J01 was explained as defined daily doses per
100 bed-days (DDD/100) according to the ATC/DDD classification. The amount of consumption was assessed with
DDD per 100 bed-days in six months.
Results: Total antibacterial
consumption was higher in Emam reza (119.62
DDD/100) than other hospitals.
Cephalosporins were the most widely used antibiotic in all five hospitals with
the total DDD per 100 bed-days of 53.74,
58.51, 46.09, 19.75 and 15.16 for Emam reza, Shohada, Sina, Shahriar and Shahid
madani ,respectively. Cefazoline had highest use among cephalosporins consumption
in all hospitals except Shahriar. Ciprofloxacin was among the five most used
antibiotics in all hospitals.
Conclusion: Although the pattern
of antibacterial consumption was almost logical in different categories of
hospitals, the total amount of DDD per 100 bed-days was dramatically more than
developed countries. Specific strategies should be employed in infection
control development and engage rational antibiotic utilization in order to
reduce future resistant strains and increase antimicrobial efficacy.