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Submitted: 18 Nov 2013

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Pharm Sci. 2012;18(2):119-132

A review on the methods and applications of spray drying technology

Original Research

Khosro Adibkia, Mohammad Barzegar Jalali * , Yosef Javadzadeh, H Maheri Esfanjani


Abstract
Spray drying is the most widely used techniqueintended for drying of pharmaceutical products as well as manufacturing of powder with desired characteristics.It is a continuous operation in which almost any pumpable liquid can be converted into a free flowing powder. Considering uniformity of formed particles and well-control on particle size, spray drying is efficiently applicable in the drug delivery systems. This method has found to be a potential way for systematic delivery of therapeutic peptides, proteins and also antibiotics. Methods: In this study, the procedures and aplications of spray drying were reviewed and the effect of diffirent affecting parameters was explained. Results: Spray drying is extensively used to dry heat sensitive products like enzymes and proteins with minimum loss on activity and produce drugs with improved solubility as well as drying of nanoparticles, microencapsulation, granulation and coating beyond its well-known background on drying of liquids





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