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Article History
Submitted: 03 Feb 2016
Revised: 07 Aug 2016
Accepted: 07 Aug 2016
First published online: 07 Aug 2016

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Pharm Sci. 2016;22(4):227-233 doi: 10.15171/PS.2016.36

Effects of Sodium Selenite on Formaldehyde Induced Renal Toxicity in Mice

Research Article

Shabnam Mohammadi 1,2 * , Maryam Moghimian 3, Hanieh Torabzadeh 4, Mahla Langari 4, Roghayeh Nazeri 4, Zahra Karimi 4, Elham Sangari 4, Najmeh Jagarmi 5, Alireza Mohammad Zadeh 3, Mehdi Karimi 7, Kamyar Tavakkoli 8, Ali Delshad 9, Fatemeh Mohammadzadeh 3, Majid Ghayour-Mobarhan 10

1 Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Microanatomy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
4 Student Research Committee, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
5 Department of Biochemistry, Payame Noor University, Mashhad, Iran.
6 Department of Public Health, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
7 Department of Clinical Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
8 Department of Urology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
9 Department of Nursing, Faculty of Nursing, Gonabad University of Medical Sciences, Gonabad, Iran.
10 Biochemistry of Nutritional Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.



Abstract
Background: Formaldehyde is widely used for industrial applications. Renal injury is an adverse effect associated with formaldehyde. Few studies have explored the potential benefits of protective factors on formaldehyde induced renal toxicity. This study evaluated the dose dependent effects of sodium selenite on the biochemical and histopathological effects of formaldehyde on murine kidney. Methods: Forty eight adult Balb/c male mice were randomized into six groups: a control group, a formaldehyde group and experimental III-VI groups. Formaldehyde group was injected with 10 mg/kg formaldehyde and groups III-VI received intraperitoneally doses of 0.1, 0.2, 0.4, 0.8 mg/kg selenium. After two weeks, a stereological study was done in accordance with the principle of Cavalieri and serum concentrations of urea and creatinine were measured. Data were analyzed using ANOVA and SPSS software. Results: Glomerosclerosis, necrosis and vacuolization were observed in the convoluted tubules of animals treated with formaldehyde. The biochemical markers, volume and count of glomeruli in the group treated with formaldehyde was significantly difference compared to the control group (P<0.05). The volume of the glomeruli in the group treated with 0.2 and 0.4 mg selenium and urea level in the group treated with 0.4 and 0.1 mg/kg selenium was significantly difference compared to the control group (P <0.05). The count of glomeruli and creatinine level in the selenium group was significantly difference compared to the control group (P ≤ 0.0001). Conclusions: A dose of 0.2 mg/kg of sodium selenite caused partial protective effect on the renal tissue and function in exposed to formaldehyde.





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Articles by Mohammadi S
Articles by Moghimian M
Articles by Torabzadeh H
Articles by Langari M
Articles by Nazeri R
Articles by Karimi Z
Articles by Sangari E
Articles by Jagarmi N
Articles by Mohammad Zadeh A
Articles by Karimi M
Articles by Tavakkoli K
Articles by Delshad A
Articles by Mohammadzadeh F
Articles by Ghayour-Mobarhan M

PubMed
Articles by Mohammadi S
Articles by Moghimian M
Articles by Torabzadeh H
Articles by Langari M
Articles by Nazeri R
Articles by Karimi Z
Articles by Sangari E
Articles by Jagarmi N
Articles by Mohammad Zadeh A
Articles by Karimi M
Articles by Tavakkoli K
Articles by Delshad A
Articles by Mohammadzadeh F
Articles by Ghayour-Mobarhan M



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