Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  

ISSN: 1735-403X      eISSN: 2383-2886  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar



Article History
Submitted: 01 May 2016
Accepted: 27 May 2016
First published online: 30 Sep 2016

Article Access Statistics
Abstract Page Views: 535
PDF Downloads: 507
Full Text Views: 0

Pharm Sci. 2016;22(3):210-214 doi: 10.15171/PS.2016.33

An Improved Automated Setup for Solubility Determination of Drugs

Short Communication

Ahmad Ghanbari 1, Yashar Sarbaz 1, Vahid Jouyban-Gharamaleki 2,3, Karim Jouyban-Gharamaleki 4, Jafar Soleymani 5, Abolghasem Jouyban 2,6 *

1 Department of Mechatronic Engineering, Faculty of Engineering Emerging Technologies, University of Tabriz, Tabriz, Iran
2 Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Mechatronic Engineering, International Campus, University of Tabriz, Tabriz, Iran
4 Tabriz Technical Training Center No. 2, Tabriz, Iran
5 Drug Applied Research Center, Tabriz University of Medical of Sciences, Tabriz, Iran
6 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran



Abstract
Background: Solubility of a drug/drug candidate is an essential information in the pharmaceutical area. Classical solubility determination method used in the laboratories are expensive and time-consuming. Attempts were made to provide an automated solubility determination setup based on a laser monitoring technique. Methods: In a previously developed setup, drug powder was added to a given quantity of the solvent which made some troubles in practical applications. The present work reports another setup which adds solvent to a given mass of the drug. The validity of the measured solubilities is checked by comparing the measured solubilities of acetaminophen at two temperatures in water and ethanol mixtures with the corresponding data from the literature. Results: The results reveal that the improved setup could overcome the limitations of the previously developed setup and could be used for drug solubility determination. Conclusion: The improved setup overcomes the troubles made in the previous setup and could be used in generating large amount of solubility data to be used in the pharmaceutical industry.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Ghanbari A
Articles by Sarbaz Y
Articles by Jouyban-Gharamaleki V
Articles by Jouyban-Gharamaleki K
Articles by Soleymani J
Articles by Jouyban A

PubMed
Articles by Ghanbari A
Articles by Sarbaz Y
Articles by Jouyban-Gharamaleki V
Articles by Jouyban-Gharamaleki K
Articles by Soleymani J
Articles by Jouyban A



Share this article!
© 2016 Tabriz University of Medical Sciences; unless otherwise stated
Press Manuscript Online. Powered by MAADRAYAN