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Journal of Cardiovascular and Thoracic Research
ISSN: 2008-5117      eISSN: 2008-6830  
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Article History
Submitted: 28 Sep 2015
Accepted: 24 Feb 2016
First published online: 14 Mar 2016

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J Cardiovasc Thorac Res. 2016;8(1):1-7 doi: 10.15171/jcvtr.2016.01
PMID:27069560        PMCID:PMC4827133

Q10 supplementation effects on cardiac enzyme CK-MB and troponin in patients undergoing coronary artery bypass graft: a randomized, double-blinded, placebo-controlled clinical trial

Original Article

Jalal Moludi 1, Seyedali Keshavarz 2, Ali Sadeghpour Tabaee 3, Saeid Safiri 4, Reza Pakzad 5 *

1 Department of Biochemistry and Diet Therapy, Faculty of Nutrition, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
3 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
4 Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran
5 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran



Abstract

Introduction: Coronary artery bypass surgery (CABG) is associated with schemia-reperfusion injury and tissue damage. CoQ10 as an antioxidant has an important role and may have cardio- protective effects after myocardial dysfunction and CABG. We aimed to evaluate whether CoQ10 has a myocardial cardio protective impact on cardiac biomarkers after CABG.
Methods: In this double-blind study, 80 patients with coronary artery disease (CAD) who underwent CABG surgery were divided into intervention and control groups and received Q10 supplement or placebo, respectively. The surgical characteristics of the patients in the two groups were similar. The intervention group received 150 mg of Q10 supplement per day for 7 days before the surgery. The control group received placebo capsule. After operation the inter- and intra-group blood levels of CK-MB and troponin, before and after supplementation and 12 hours after the CABG, and postoperative outcomes such as intensive care unit (ICU) stay and hospital stay were compared.
Results: In this study, 40 subjects were located in each group. The participation rate was 97.5% and men and women accounted for 52.5% and 47.5% respectively. The mean age of the subjects was 58.17 ± 8.55. The two groups were not significantly different in terms of basic variables. Within-group comparison showed a significant increase in the level of troponin enzymes over time (P < 0.001) and CK-MB (P < 0.001). However, between-group comparison showed no significant difference between the two groups in terms of CK-MB (P = 0.384) and troponin (P = 0.115). In the end, no interaction was observed between the intervention and time on CK-MB (P = 0.095) and troponin (P = 0.198) variables.
Conclusion: Q10 supplementation 7 days before surgery was not effective in reducing CK-MB and troponin after CABG.







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