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J Anal Res Clin Med. 2013;1(2): 96-100.
doi: 10.5681/jarcm.2013.014
  Abstract View: 1098
  PDF Download: 812

Original Research

Seroprevalence of Cytomegalovirus in blood donors in the northwest of Iran

Jamal Eivazi-Ziaei 1*, Aliakbar Movassaghpour 2, Mohammad Asgharzadeh 3, Saeed Dastgiri 4

1 Professor, Department of Internal Medicine, Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Assistant Professor, Department of Immunology, Hematology Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Professor, Department of Biochemistry, Tabriz University of Medical Sciences, Tabriz, Iran
4 Professor, Department of Epidemiology, Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz,Iran
*Corresponding Author: Email: jeziaei@yahoo.com

Abstract

BACKGROUND: Cytomegalovirus (CMV) is the causal agent of infection in immunocompromised patients andtransplant recipients, or those patients who receive blood transfusion frequently. Seroprevalence of CMV has beenreported to be highest in South America, Africa, and Asia, and lowest in Western Europe and United States. Datareferring to the prevalence of anti-CMV antibody among healthy people in Iran is scanty, but its incidence may reach100% among blood donors and recipients, likely due to condensed population and socio-economic status. METHODS: The blood specimens of 200 volunteer donors were tested through ELISA for anti-CMV immunoglobulinG (IgG) and immunoglobulin M (IgM) antibodies in our hospital. RESULTS: According to these analyses, 98.5% and 85% of the specimens were found to be positive for anti-CMV IgGand IgM antibodies, respectively. This study shows that like other regions, anti-CMV seropositivity is high in Iran andblood transfusion is an important route of CMV spread. CONCLUSIONS: Since up to 95% of blood donors in Iran are seropositive for CMV, it would seem superfluous toscreen blood donors for CMV, as few seronegative blood units would be available for transfusion. Leukoreductioncould be a more appropriate and cost-effective prevention of transmission of CMV through infected blood in Iran. 
Keywords: Blood, Cytomegalovirus, Iran
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Submitted: 04 Aug 2013
Accepted: 01 Oct 2013
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