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Journal of Analytical Research in Clinical Medicine
   eISSN: 2345-4970  
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Article History
Submitted: 31 Aug 2015
Accepted: 08 Dec 2015

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J Anal Res Clin Med. 2016;4(1):9-13 doi: 10.15171/jarcm.2016.002

Analysis ulcerative colitis for presence Epstein-Barr virus DNA sequences by polymerase chain reaction technique

Original Research

Sahar Mehrabani khasraghi 1 * , Mitra Ameli 2, Farzad Khalily 3

1 Microbiologist, Department of Microbiology, School of Basic Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran
2 Assistant Professor, Liver and Gastrointestinal Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Assistant Professor, Liver and Gastrointestinal Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran


See erratum "Erratum to: Analysis ulcerative colitis for presence of Epstein-Barr virus DNA sequences by polymerase chain reaction technique"

Abstract
Introduction: Ulcerative colitis (UC) is one type of inflammatory bowel disease (IBD). The purpose of this study is to explore the prevalence of Epstein–Barr virus (EBV) in UC patients in comparison with healthy subjects using the polymerase chain reaction (PCR) method. Methods: In this case-control study, five biopsies of patients with UC and 30 healthy people as controls were selected. Sampling was performed by endoscopic biopsy operation. After DNA extraction, PCR was used to determine EBV genome by specific primers. Statistical analysis was performed using the chi-square test. Results: The results of PCR indicated that EBV genome was detected in 60.0% of samples in the case group, and 36.7% of samples in the control group were positive for EBV. Thus, no significant association was observed between the prevalence of EBV and incidence of UC in comparison with the control group (P = 0.36). Conclusion: The findings presented herein demonstrate no direct molecular evidence to support an association of EBV with UC. These results, do not exclude the possibility oncogenic role of EBV to infect the different colon cell.





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