tbzmedTabriz University of Medical SciencesAPBAdvanced Pharmaceutical BulletinPerspectiveAdvanced Pharmaceutical BulletinHLA-G Expression Pattern: Reliable Assessment for Pregnancy Outcome PredictionPregnancy outcome prediction using HLA-G expression patternMosaferiElnazImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Tabriz International University of Medical Sciences, Tabriz, Iran, MajidiJafarImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, MohammadianMojdehHematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, BabalooZohrehImmunology Research Center,Tabriz university of Medical Sciences. Tabriz. Iran., MonfaredanAmirDepartment of Hematology, Faculty of Medicine, Tabriz Branch of Islamic Azad University, Tabriz, Iran, BaradaranBehzadImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, 12201330122013321242013Tabriz University of Medical Sciences2013HLA-G Expression Pattern: Reliable Assessment for Pregnancy Outcome Prediction

Because mothers and fathers are more or less dissimilar at multiple HLA loci, mother considers her fetus as a semi-allograft. Mother's immune system may recognize paternal HLA as foreign antigen and may develop anti-paternal HLA antibodies and cytotoxic T lymphocyte. There are some mechanisms that modulate maternal immune responses during pregnancy, in order to make uterus an immune privileged site. This immunosuppression is believed to be mediated, at least partly, by HLA-G, non-classical class I human leukocyte antigen (HLA) molecule that is strongly expressed in cytotrophoblast and placenta. The major HLA-G function is its ability to inhibit T and B lymphocytes, NK cells and antigen-presenting cells (APC).Since HLA-G is expressed strongly at the maternofetal interface and has an essential role in immunosuppression, HLA-G polymorphism and altered expression of HLA-G seems to be associated with some complications of pregnancy, such as pre-eclampsia, recurrent misscariage and failure in IVF.This perspective discusses recent findings about HLA-G genetics, function, expression and polymorphism; and focus on HLA-G role in the etiology of recurrent miscarriage.