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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 29 Dec 2015
Revised: 18 Jan 2017
Accepted: 25 Jan 2017
First published online: 13 Apr 2017

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Adv Pharm Bull. 2017;7(1):11-20 doi: 10.15171/apb.2017.003

Novel Pentablock Copolymers as Thermosensitive Self-Assembling Micelles for Ocular Drug Delivery

Review Article

Mitra Alami-Milani 1,2, Parvin Zakeri-Milani 1,3, Hadi Valizadeh 1,3, Roya Salehi 4, Sara Salatin 1,4, Ali Naderinia 5, Mitra Jelvehgari 1,3 *

1 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
3 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran.
5 Department of Mechanical Engineering, Tabriz Branch, Islamic Azad University, Tabriz, Iran.



Abstract
Many studies have focused on how drugs are formulated in the sol state at room temperature leading to the formation of in situ gel at eye temperature to provide a controlled drug release. Stimuli-responsive block copolymer hydrogels possess several advantages including uncomplicated drug formulation and ease of application, no organic solvent, protective environment for drugs, site-specificity, prolonged and localized drug delivery, lower systemic toxicity, and capability to deliver both hydrophobic and hydrophilic drugs. Self-assembling block copolymers (such as diblock, triblock, and pentablock copolymers) with large solubility variation between hydrophilic and hydrophobic segments are capable of making temperature-dependent micellar assembles, and with further increase in the temperature, of jellifying due to micellar aggregation. In general, molecular weight, hydrophobicity, and block arrangement have a significant effect on polymer crystallinity, micelle size, and in vitro drug release profile. The limitations of creature triblock copolymers as initial burst release can be largely avoided using micelles made of pentablock copolymers. Moreover, formulations based on pentablock copolymers can sustain drug release for a longer time. The present study aims to provide a concise overview of the initial and recent progresses in the design of hydrogel-based ocular drug delivery systems.






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Articles by Alami-Milani M
Articles by Zakeri-Milani P
Articles by Valizadeh H
Articles by Salehi R
Articles by Salatin S
Articles by Naderinia A
Articles by Jelvehgari M

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Articles by Alami-Milani M
Articles by Zakeri-Milani P
Articles by Valizadeh H
Articles by Salehi R
Articles by Salatin S
Articles by Naderinia A
Articles by Jelvehgari M



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