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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Submitted: 12 Feb 2014
Revised: 01 Jun 2014
First published online: 05 Mar 2015

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Adv Pharm Bull. 2015;5(1):127-132 doi: 10.5681/apb.2015.018
PMID:25789230        PMCID:PMC4352215

The Effect of Regular Moderate Exercise on miRNA-192 Expression Changes in Kidney of Streptozotocin-Induced Diabetic Male Rats

Original Research

Hajar Oghbaei 1, Naser Ahmadi Asl 1 * , Farzam Sheikhzadeh 2, Mohammad Reza Alipour 1, Amir Mahdi khamaneh 3

1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
3 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: The purpose of this study was to investigate the regular moderate exercise effect on the miR-192 expression changes in kidney of Streptozotocin- induced diabetic rats. Methods: Forty adult male Wistar rats were divided into four groups of 10, including Sedentary Control group, Healthy 60 days Exercise group, diabetic group and Diabetic 60 days Exercise. Diabetes was induced by injection of 60 mg/kg Streptozotocin and after 48 hour blood glucose levels higher than 250 mg/dl were included to diabetic rats. After 48 hour of induction diabetes, exercise protocol was begun. Animals performed 5 days of consecutive treadmill exercise (60 min/day) with 22 m/min speeds for 60 days. Kidney of the rats has removed and MicroRNA was extracted from kidney using miRCURYTM RNA isolation kit. Results: Exercise upregulated miR-192 expression level significantly in the kidney of diabetic rats in comparison to healthy group. There is not any significant change in miR-192 expression in diabetic 60 days exercise compared to control group. Conclusion: These results may indicate that exercise can help to prevent the progression of diabetic nephropathy.

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