Purpose: This study aims to prepare a novel, natural
nanoparticle (NP) as a drug carrier, which also has inherent therapeutic
Methods: Pistacia khinjuk gum NPs were prepared and Response surface methodology
(RSM) was used for statistical analysis of data and optimizing the size of NPs.
were in the range of
75.85–241.3 nm. The optimization study was carried
out, and an optimized size (70.86nm) was obtained using DMSO as a solvent. The
volume of the organic phase was 111.25µl, and the concentration of gum was 1%
w/v. The cell viability assay was performed on the pure gum and NPs
toward β-TC3, MCF7, and HT29 cell lines. It was observed that NPs
have higher cytotoxic activity in comparison with pure gum, and that the IC50value
was achieved at 1% of NPs in β-TC3 cells. The obtained NPs
demonstrated antibacterial activity against two bacterial strains (Pseudomonas
aeruginosa and Staphylococcus aureus).
Altogether, according to the obtained results, these NPs with inherent
cytotoxicity and antibacterial activity are an attractive carrier for drug