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Advanced Pharmaceutical Bulletin
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Submitted: 07 Dec 2014
Revised: 15 Apr 2015

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Adv Pharm Bull. 2015;5(3):299-304 doi: 10.15171/apb.2015.042
PMID:26504750        PMCID:PMC4616896

The Impact of Mesenchymal Stem Cells on Differentiation of Hematopoietic Stem Cells

Review Article

Mahshid Saleh 1, karim Shamsasanjan 1,2 * , Aliakbar Movassaghpourakbari 1, Parvin Akbarzadehlaleh 3, Zahra Molaeipour 1

1 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
3 Department of Pharmaceutical Biotechnology, Tabriz University of Medical Science, Tabriz, Iran.



Abstract
Bone marrow microenvironment contains cellular and acellular compartments. The cellular compartment includes hematopoietic stem cells, mesenchymal stem cells and some other stromal cell types, while the acellular compartment is composed of scaffold proteins known as the extra cellular matrix. Direct cell-cell contact as well as cytokines secreted by mesenchymal stem cells during coculture of hematopoietic stem cells and mesenchymal stem cells play a critical role in hematopoiesis, and determines the fate of hematopoietic stem cells. Several studies have demonstrated the impact of mesenchymal stem cells on self-renewal, expansion, proliferation and differentiation of hematopoietic stem cells in vitro, which have shown different and contradictory results. In this paper, we will investigate the effect of mesenchymal stem cells on differentiation of hematopoietic stem cells in vitro.





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