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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 27 Jun 2014
Revised: 02 Jun 2015
Accepted: 30 Jul 2015
First published online: 30 Nov 2015

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Adv Pharm Bull. 2015;5(4):537-548 doi: 10.15171/apb.2015.073
PMID:26819927        PMCID:PMC4729344

Oleic Acid Coated Gelatin Nanoparticles Impregnated Gel for Sustained Delivery of Zaltoprofen: Formulation and Textural Characterization

Original Research

Vishal Pande 2 * , Savita Pawar 1

1 R.C. Patel College of Pharmaceutical Education and Research, Shirpur, India 425405.
2 Sanjivani College of Pharmaceutical Education and Research, Kopargaon, India 423603.



Abstract

Purpose: In the present study, we have formulated zaltoprofen loaded, surface decorated, biodegradable gelatin nanogel and evaluated its texture characterization.

Methods: The method used to prepare gelatin nanoparticles (GNP) was ‘two step desolvation’ and its surface decoration was performed with oleic acid (OA). The GNP was optimized by DOE software. Nanogels were evaluated for particle size entrapment efficiency, texture properties, SEM, in-vitro, ex-vivo drug release studies, in-vitro characterization, stability and in vivo evaluation of nanogel for anti-inflammatory activity was carried out by carrageenan induced rat paw edema method as an anti-inflammatory experimental model.

Results: The formulated GNP with particle size and entrapment efficiency of optimized batch was found to be 247.1 nm and 76.21% respectively. The SEM of GNP shows smooth and spherical shape. In-vitro and Ex-vivo drug release shows that there was 69.47% and 78.59% drug released within 48 hrs. It follows Ritger peppas model, which indicates sustained drug release. The good texture properties of nanogel were observed from texture analysis graphs.In vivo studies of our formulation give significant results compared to the marketed nanogel. Stability data revealed stability of nanogel formulation up to 3 months.

Conclusion: The present approach can provide us promising results of the sustained analgesic activity and the stability of drug within the GNP.







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