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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 27 Jul 2013
Revised: 20 Oct 2013
First published online: 24 Dec 2013

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Adv Pharm Bull. 2014;4(2):191-195 doi: 10.5681/apb.2014.028
PMID:24511484        PMCID:PMC3915820

Formulation and Quality Determination of Indapamide Matrix Tablet: A Thiazide Type Antihypertensive Drug

Original Research

Jannatun Tazri 1, Md. Mizanur Rahman Moghal 1 * , Syed Masudur Rahman Dewan 1, Wahiduzzaman Noor 1, Nor Mohammad 2

1 Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh.
2 Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh.



Abstract
Purpose: The present study was explored to develop a sustained release matrix tablet of Indapamide, a low-dose thiazide-type diuretic, using hydroxylpropyl methylcellulose (Methocel K15MCR) in various proportions as release controlling factor. Methods: The tablets were formulated using direct compression method. The powers for tableting were evaluated for angle of response, loose bulk density, tapped bulk density, compressibility index, total porosity and drug content etc. The tablets were subjected to thickness, weight variation test, drug content, hardness, friability, and in vitro dissolution studies. Results: The granules showed satisfactory flow properties, compressibility index, and drug content. All the formulated tablets complies pharmacopoeia specifications. The release kinetics of the drug decreased exponentially with the addition of polymer concentration. Indapamide release rate was observed to be the highest with the lowest concentration of polymer used. The release mechanism was explored with zero order, first order, Higuchi and Krosmeyer equations. Stability tests of the drug showed no notable changes in the rate of drug release, related substances and drug content. Conclusion: In the context, it can be suggested that this formulation of sustained release Indapamide tablets can be marketed to treat patients with hypertension ensuring proper healthcare.





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