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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Submitted: 10 Apr 2013
Revised: 15 May 2013
First published online: 24 Dec 2013

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Adv Pharm Bull. 2014;4(2):101-104 doi: 10.5681/apb.2014.016
PMID:24511472        PMCID:PMC3915808

Synthesis, Characterization and Antioxidant Property of Quercetin-Tb(III) Complex

Original Research

Jafar Ezzati Nazhad Dolatabadi 1, Ahad Mokhtarzadeh 2, Seyed Morteza Ghareghoran 1, Gholamreza Dehghan 3 *

1 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Plant Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.

Purpose: Nearly all of flavonoids are good metal chelators and can chelate many metal ions to form different complexes. This article describes a synthesis of Quercetin–Tb(III) in methanol, characterized by using elemental analysis, UV–visible and evaluation of its antioxidant properties.Methods: The formation of complexes is realized from the UV–visible spectra which shows that the successive formation of Quercetin–Tb(III) occurs. To find out the antioxidant activity variation and the role of Tb(III) ion on the antioxidant activity of the complexes different radical scavenging methods such as: 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and 2,2′-azinobis 3-ethylbenzothiazoline-6-sulphonic acid (ABTS) were used.Results: The results from DPPH, ABTS and FRAP methods showed that Quercetin and Quercetin–Tb(III) complex are capable of donating electron or hydrogen atom, and consequently could react with free radicals or terminate chain reactions in a time- and dose-dependent manner.Conclusion: This study showed that the chelation of metal ions by Quercetin decrease the redox potential of Quercetin-metal complex.

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Articles by Ezzati Nazhad Dolatabadi J
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Articles by Ezzati Nazhad Dolatabadi J
Articles by Mokhtarzadeh A
Articles by Ghareghoran SM
Articles by Dehghan G

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