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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 14 Mar 2013
Revised: 24 Apr 2013
First published online: 20 Aug 2013

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Adv Pharm Bull. 2013;3(2):469-472 doi: 10.5681/apb.2013.078
PMID:24312881        PMCID:PMC3848221

Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate Technique

Original Research

Kandikonda Sandeep * , Madhusudhanareddy Induri, Muvvala Sudhakar


Abstract
Purpose: An accurate and precise UV spectrophotometric method with multivariate calibration technique for the determination of aripiprazole in pharmaceutical formulations has been described. Methods: This technique is based on the use of the linear regression equations by using the relationship between concentration and absorbance at five different wavelengths. The aripiprazole shows absorption maxima at 255 nm and obeyed Beer’s law in the range of 5-30 µg/mL. Results: The results were treated statistically and were found highly accurate, precise and reproducible. This statistical approach gives optimum results for the eliminating fluctuations coming from instrumental or experimental conditions. Conclusion: It was concluded that the proposed method is simple, easy to apply, economical and could be used as an alternative to the existing spectrophotometric and non-spectrophotometric methods for the routine analysis of aripiprazole in pharmaceutical formulations.





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