Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(0)


Article History
Submitted: 19 Mar 2013
Revised: 24 Jul 2013
First published online: 23 Dec 2013

Article Access Statistics
Abstract Page Views: 235
PDF Downloads: 129
Full Text Views: 0

Adv Pharm Bull. 2014;4(1):35-42 doi: 10.5681/apb.2014.006
PMID:24409407        PMCID:PMC3885366

Anxiogenic Effects of Acute Injection of Sesame oil May be Mediated by β-1 Adrenoceptors in the Basolateral Amygdala;-1 Adrenoceptors in the Basolateral Amygdala

Original Research

Mahnaz Kesmati 1, Maysam Mard-Soltani 1 * , Lotfolah Khajehpour 1

1 Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, Iran.



Abstract
Purpose: A few studies have indicates that the sesame oil influences anxiety, but many reports show that β-1 adrenoceptors (ARs) of the basolateral amygdala (BLA) plays a pivotal role in this regard. Therefore, in this study the effect of acute injection of sesame oil on anxiety-like behavior in the presence and absence of the BLA β-1 ARs in the male Wistar rats were investigated. Methods: Guide cannulas, for seven groups of rats, were implanted bilaterally into the BLA. Two weeks after the stereotaxic surgery, anxiety-like behaviors (the OAT%, OAE % and locomotor activity) were evaluated by Elevated Plus-Maze (EPM) for all groups. 3 groups received different volumes of sesame oil (i.p.) and they were compared with control group (received saline via i.p.), and the anxiogenic volume of sesame oil (1.5ml/kg) was determined. Then, 3 other groups received constant effective volume of sesame oil (1.5ml/kg) along with 3 different doses of betaxolol, selective β-1 ARs antagonist, intra BLA microinjection in order to be compared with sesame oil group (1.5 ml/kg). Results: The acute injection of sesame oil with the volume dependent manner showed an anxiogenic effect with reduction of the OAT% and OAE% which the maximum effect of sesame oil was observed in the dose of 1.5mg/kg. Also, betaxolol with dose dependent manner attenuated the anxiogenic effects of sesame oil (1.5mg/kg), but this reduction could not remove the anxiety effects completely. Conclusion: It seems that the sesame oil acute (i.p.) injection induces anxiety, and this effect is attenuated by inhibition of β-1ARs in the BLA.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Kesmati M
Articles by Mard-Soltani M
Articles by Khajehpour L

PubMed
Articles by Kesmati M
Articles by Mard-Soltani M
Articles by Khajehpour L

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN