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Article History
Submitted: 06 Jul 2016
Revised: 22 Oct 2016
Accepted: 26 Oct 2016
First published online: 22 Dec 2016

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Adv Pharm Bull. 2016;6(4):573-579 doi: 10.15171/apb.2016.071

Anti-Inflammatory and Antibothropic Properties of Jatropha Elliptica, a Plant from Brazilian Cerrado Biome

Research Article

Sára Costa Ferreira-Rodrigues 1, Cássio Milhomens Rodrigues 1, Marcio Galdino Dos Santos 1, Jean Antonio Abraham Gautuz 2, Magali Glauzer Silva 2, José Carlos Cogo 3, Camila Batista-Silva 4, Cleiton Pita Dos Santos 4, Francisco Carlos Groppo 4, Karina Cogo-Müller 4,5, Yoko Oshima-Franco 2 *

1 Environmental Sciences Post-Graduate Program, PGCiamb, Tocantins Federal University (UFT), Palmas, Tocantins, Brazil.
2 Post-Graduate Program in Pharmaceutical Sciences and Pharmacy, University of Sorocaba (UNISO), Sorocaba, SP, Brazil.
3 Post-Graduate Program in Animal Production, University Camilo Castelo Branco (UNICASTELO), Descalvado, SP, Brazil.
4 Piracicaba Dental School, Department of Pharmacology, University of Campinas (UNICAMP), Piracicaba, SP Brazil.
5 Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Rua Sérgio Buarque de Holanda, Campinas, SP, Brazil.



Abstract
Purpose: The aim of this study was to evaluate the antibothropic and anti-inflammatory properties of J. elliptica. Methods: Phytochemical screening and thin-layer chromatography (TLC) assays were performed on J. elliptica hydroalcoholic extract (TE) in order to observe its main constituents. The antibothropic activity of TE was evaluated by the in vitro neuromuscular blockade caused by Bothrops jararacussu venom (Bjssu), in a mouse phrenic nerve-diaphragm model (PND). A quantitative histological study was carried out to observe a possible protection of TE against the venom myotoxicity. The anti-inflammatory activity was also evaluated in two models, Bjssu-induced paw edema, and carrageenan-induced neutrophils migration in the peritoneal cavity. Results: TLC analysis revealed several compounds in TE, such as saponins, alkaloids, and phenolic constituents. TE was able to neutralize the blockade and the myotoxicity induced by venom, when it was pre-incubated for 30 min with venom. In addition, it showed anti-inflammatory activity, inducing less neutrophils migration and reducing paw edema. Conclusion: J. elliptica showed both antibothropic and anti-inflammatory properties.





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Articles by Ferreira-Rodrigues SC
Articles by Rodrigues CM
Articles by Dos Santos MG
Articles by Gautuz JA
Articles by Silva MG
Articles by Cogo JC
Articles by Batista-Silva C
Articles by Dos Santos CP
Articles by Groppo FC
Articles by Cogo-Müller K
Articles by Oshima-Franco Y

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Articles by Ferreira-Rodrigues SC
Articles by Rodrigues CM
Articles by Dos Santos MG
Articles by Gautuz JA
Articles by Silva MG
Articles by Cogo JC
Articles by Batista-Silva C
Articles by Dos Santos CP
Articles by Groppo FC
Articles by Cogo-Müller K
Articles by Oshima-Franco Y



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