Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar



Article History
Submitted: 22 Jun 2016
Revised: 22 Aug 2016
Accepted: 24 Aug 2016
First published online: 25 Sep 2016

Article Access Statistics
Abstract Page Views: 205
PDF Downloads: 150
Full Text Views: 0

Adv Pharm Bull. 2016;6(3):443-447 doi: 10.15171/apb.2016.057

Evaluation of Betulin Mutagenicity by Salmonella/Microsome Test

Short Communication

Edson Hideaki Yoshida 1, Natália Tribuiani 1, Giovana Sabadim 1, Débora Antunes Neto Moreno 1, Eliana Aparecida Varanda 2, Yoko Oshima-Franco 1 *

1 Post-Graduate Program in Pharmaceutical Sciences, University of Sorocaba (UNISO), Sorocaba, SP, Brazil.
2 Pharmaceutical Sciences Faculty of Araraquara, São Paulo State University (UNESP), Rodovia Araraquara-Jau, Km 1, CEP 14801-902, Araraquara, São Paulo, Brazil.



Abstract
Purpose: Betulin is a pentacyclic triterpene found in the outer barks of innumerous plants. This secondary metabolite is easily isolated from plants with the major interest in converting it to betulinic acid, which pharmacological properties were much more exploited than betulin. But, investments in the own betulin have been grown since no chemical step is necessary. In this study we focused the precursor betulin in order to evaluate its mutagenicity by Salmonella/microsome assay (Ames test). Methods: The Ames test was carried out using a commercial betulin exposed to Salmonella typhimurium strains TA98, TA100, TA102, and TA97a, in experiments with (+S9) and without (-S9) metabolic activation. Results: Betulin was unable to increase the number of revertants (+S9 and -S9 metabolic activation) showing the absence of any mutagenic effect by Ames test.Conclusion: This study allowed attribute safety to betulin being important for exploiting its pharmacological uses.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Yoshida EH
Articles by Tribuiani N
Articles by Sabadim G
Articles by Neto Moreno DA
Articles by Varanda EA
Articles by Oshima-Franco Y

PubMed
Articles by Yoshida EH
Articles by Tribuiani N
Articles by Sabadim G
Articles by Neto Moreno DA
Articles by Varanda EA
Articles by Oshima-Franco Y



Share this article!

Press Manuscript Online. Powered by MAADRAYAN