Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(4)


Article History
Submitted: 26 Jan 2013
Revised: 18 Apr 2013
First published online: 20 Aug 2013

Article Access Statistics
Abstract Page Views: 214
PDF Downloads: 110
Full Text Views: 0

Adv Pharm Bull. 2013;3(2):385-393 doi: 10.5681/apb.2013.062
PMID:24312865        PMCID:PMC3848234

Rhizomes of Eremostachys laciniata: Isolation and Structure Elucidation of Chemical Constituents and a Clinical Trial on Inflammatory Diseases

Original Research

Abbas delazar * , Satyajit D. Sarker, Lutfun Nahar, Shahriar Barzegar Jalali, Masoud Modaresi, Sanaz Hamedeyazdan, Hossein Babaei, Yousef Javadzadeh, Solmaz Asnaashari, Sadeighe Bamdad Moghadam


Abstract
Purpose: The purpose of this study was the isolation and structure elucidation of chemical compounds from the rhizomes of Eremostachys laciniata (L) Bunge (EL), an Iranian traditional medicinal herb with a thick root and pale purple or white flowers as well as the clinical studies on the therapeutic efficacy and safety of topical application of the EL extract in the management of some inflammatory conditions, e.g., arthritis, rheumatoid arthritis and septic arthritis (Riter’s syndrome). Methods: The structures of the isolated compounds were elucidated unequivocally on the basis of one and two dimensional NMR, UV and HR-FABMS spectroscopic data analyses. A single-blinded randomized clinical trial was carried out with the extract of the rhizomes of E. laciniata (EL) to determine the efficacy and safety of the traditional uses of EL compared to that of piroxicam in treatment of inflammatory diseases, e.g., osteoarthritis, rheumatoid arthritis and Reiter’s syndrome. Results: Eleven iridoid glycosides, two phenylethanoids and two phytosterols were isolated and identified for the first time from the rhizomes of EL. After 14 days of treatment with the EL and piroxicam ointments, all groups showed significant improvements compared to the control groups. EL (5%) ointment induced better initial therapeutic response than piroxicam (5%) onitment. Conclusion: This clinical trial established that EL was suitable for topical applications as a safe and effective complementary therapy for inflammatory diseases.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by delazar A
Articles by Sarker SD
Articles by Nahar L
Articles by Jalali SB
Articles by Modaresi M
Articles by Hamedeyazdan S
Articles by Babaei H
Articles by Javadzadeh Y
Articles by Asnaashari S
Articles by Bamdad Moghadam S

PubMed
Articles by delazar A
Articles by Sarker SD
Articles by Nahar L
Articles by Jalali SB
Articles by Modaresi M
Articles by Hamedeyazdan S
Articles by Babaei H
Articles by Javadzadeh Y
Articles by Asnaashari S
Articles by Bamdad Moghadam S

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN