Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(3)


Article History
Submitted: 14 Jan 2013
Revised: 05 Feb 2013
First published online: 20 Aug 2013

Article Access Statistics
Abstract Page Views: 196
PDF Downloads: 92
Full Text Views: 0

Adv Pharm Bull. 2013;3(2):283-288 doi: 10.5681/apb.2013.046
PMID:24312849        PMCID:PMC3848223

Effect of Vitamin B6 on Clinical Symptoms and Electrodiagnostic Results of Patients with Carpal Tunnel Syndrome

Original Research

Mahnaz Talebi * , Sasan Andalib * , Shohreh Bakhti, Hormoz Ayromlou, Alireza Aghili, Ashraf Talebi


Abstract
Purpose: Carpal tunnel syndrome (CTS) refers to a cluster of signs and symptoms that stems from compression of the median nerve traveling through carpal tunnel. Surgery is a definite treatment for CTS; however, many conservative therapies have been proposed. The present study set out to assess the effect of vitamin B6 in patients with CTS. Methods: Forty patients (67 hands) with mild-moderate CTS were initially selected and randomly assigned into two groups as follows: 1) Case group with 20 subjects (32 affected hands) receiving vitamin B6 (120 mg/day for 3 months) and splinting. 2) Control group with 19 subjects (35 affected hands) only received splinting. One subject from the control group dispensed with continuing participation in the research. Daily symptoms and electrodiagnostic (NCV-EMG) results were assessed at baseline and after 3 months. Results: Nocturnal awakening frequency due to pain, daily pain, daily pain frequency, daily pain persistence, hand numbness, hand weakness, hand tingling, severity of nocturnal numbness and tingling, nocturnal awakening frequency owing to hand numbness and tingling, and clumsiness in handling objects improved significantly in the vitamin B6-treated patients; even so, only problem with opening a jam bottle and handling phone significantly reduced in the control group. The median nerve sensory latency mean decreased following the treatment; and the median nerve sensory amplitude mean and sensory conduction velocity mean increased. Conclusion: The present study suggests that vitamin B6 treatment improves clinical symptoms and sensory electrodiagnostic results in CTS patients, and thus is recommended for CTS treatment.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Talebi M
Articles by Andalib S
Articles by Bakhti S
Articles by Ayromlou H
Articles by Aghili A
Articles by Talebi A

PubMed
Articles by Talebi M
Articles by Andalib S
Articles by Bakhti S
Articles by Ayromlou H
Articles by Aghili A
Articles by Talebi A

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN