Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(2)


Article History
Submitted: 27 Jan 2013
Revised: 26 Feb 2013
First published online: 20 Aug 2013

Article Access Statistics
Abstract Page Views: 221
PDF Downloads: 138
Full Text Views: 0

Adv Pharm Bull. 2013;3(2):457-459 doi: 10.5681/apb.2013.075
PMID:24312878        PMCID:PMC3848212

Antinociceptive Activity and Effect of Methanol Extracts of Three Salvia Spp. on Withdrawal Syndrome in Mice

Short Communication

Mohammad Karami * , Mohammad Mehdi Shamerani, Ebrahim Hossini, Ahmad Reza Gohari, Mohammad Ali Ebrahimzadeh, Anahita Nosrati


Abstract
Purpose: There are several reports about effects of Salvia spp. on CNS. The present experiment is undertaken to study effect of S. limbata, S. hypoleuca and S. macrosiphon on withdrawal syndrome in mice. Methods: Antinociceptive activities of aerial parts of Salvia spp. is investigated using hot plate method. In addition, the effect of its aerial parts on morphine dependence is investigated in mice. After induction of morphine dependency, different concentrations of plant extract are injected. To assess morphine withdrawal, naloxone (5 mg kg-1, i.p.) are injected into mice on the 5th day. Withdrawal syndrome is assessed by placing each mouse in a glass box 30 cm in height and recording the incidence of escape jumps for 60 minutes. Results: A decrease in incidence of escape jumps is observed in morphine dependence mice. S. limbata and S. hypoleuca extracts produced a statistically significant inhibition of pain induced by hot plate latency at (500, 1000 and 1500 mg kg-1) i.p. A significant increase in pain threshold is observed after 30 and 60 minutes (p < 0.001). The activity was comparable to that of morphine (30 mg kg-1, i.p., p> 0.05). The antinociceptive activity increased up to 60 minutes. Conclusion: S. limbataand S. hypolecuca extracts produced statistically significant inhibition of pain and development of morphine dependence in mice.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Karami M
Articles by Shamerani MM
Articles by Hossini E
Articles by Gohari AR
Articles by Ebrahimzadeh MA
Articles by Nosrati A

PubMed
Articles by Karami M
Articles by Shamerani MM
Articles by Hossini E
Articles by Gohari AR
Articles by Ebrahimzadeh MA
Articles by Nosrati A

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN