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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 28 Oct 2012
Revised: 19 Nov 2012
First published online: 07 Feb 2013

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Adv Pharm Bull. 2013;3(1):153-159 doi: 10.5681/apb.2013.026
PMID:24312829        PMCID:PMC3846055

Synthesis, Characterization and Antimicrobial Activity of Certain Novel Aryl Hydrazone Pyrazoline-5-Ones Containing Thiazole Moiety

Original Research

Maliki Reddy Dastagiri Reddy, Aluru Raghavendra Guru Prasad * , Yadati Narasimha Spoorthy, Lakshmana Rao Krishna Rao Ravindranath


Abstract
Purpose: The aim of this article is to synthesize, characterize and evaluate the antimicrobial activity of certain novel 3-methyl-5-oxo-4-(phenyl hydrazono)-4,5-dihydro-pyrazol-1-yl]-acetic acid N|-(4-substituted thiazol-2-yl)-hydrazides. Methods: The synthesized compounds were characterized by elemental analysis and IR, NMR and mass spectral data. The antimicrobial activity of novel compounds was evaluated by broth dilution method. Results: XVe, XVf and XVg have shown better antibacterial activity than other compounds of the series. XVa, XVc, XVd and XVe have shown better antifungal activity than the other compounds of the series. Conclusion: All compounds were found to exhibit fair degree of antimicrobial activity.





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