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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 24 Oct 2012
Revised: 28 Nov 2012
First published online: 07 Feb 2013

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Adv Pharm Bull. 2013;3(1):197-201 doi: 10.5681/apb.2013.032
PMID:24312835        PMCID:PMC3846047

Virulence and Antimicrobial Resistance in Enterococci Isolated from Urinary Tract Infections

Original Research

Yaeghob Sharifi, Alka Hasani * , Reza Ghotaslou, Behrouz Naghili, Mohammad Aghazadeh, Mortaza Milani, Ahad Bazmany


Abstract
Purpose: Urinary tract infection (UTI) is the most common nosocomial infection among hospitalized patients. Meanwhile, most frequent infections involving enterococci affect the urinary tract. The aims of this study were to investigate the susceptibility pattern of isolated enterococci from UTI and the prevalence of virulence genes. Methods: The study used enterococci isolated from urinary tract infections obtained from 3 university teaching hospitals in Northwest Iran. The antimicrobial susceptibility of the strains was determined using the disc diffusion method. Multiplex PCR was performed for the detection of genus- species specific targets, and potential virulence genes. Results: Of 188 enterococcal isolates, 138 (73.4%) and 50 (26.6%) were Enterococcus faecalis and E. faecium, respectively. Antibiotic susceptibility testing showed high resistance to amikacin (86.2%), rifampicin (86.2%) and erythromycin (73.9%), irrespective of species. In total, 68.1% were positive for gelE, and 57.4%, 53.2%, 56.4%, and 52.1% of isolates were positive for cpd, asa1, ace, and esp, respectively. Conclusion: The study revealed that most of UTI isolates were multidrug resistance against the antibiotics tested and antibiotic resistance was more common among E. faecium isolates than E. faecalis. A significant correlation was found between UTI and the presence of gelE among E. faecalis strains (p< 0.001).





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