Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Export citation
Reference Manager

Cite by
Google Scholar

Article History
Submitted: 20 May 2015
Revised: 20 Jun 2015
Accepted: 30 Jul 2015
First published online: 30 Nov 2015

Article Access Statistics
Abstract Page Views: 430
PDF Downloads: 228
Full Text Views: 0

Adv Pharm Bull. 2015;5(4):523-529 doi: 10.15171/apb.2015.071
PMID:26819925        PMCID:PMC4729354

Thermal Analysis Investigation of Dapoxetine and Vardenafil Hydrochlorides using Molecular Orbital Calculations

Original Research

Ali Kamal Attia 1 * , Eglal R. Souaya 2, Ethar A. Soliman 1

1 National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.
2 Department of Chemistry, Faculty of Science, Ain Shams University, Egypt.


Purpose: Thermal analysis techniques have been used to study the thermal behavior of dapoxetine and vardenafil hydrochlorides and confirmed using semi-empirical molecular orbital calculations.

Methods: Thermogravimetric analysis, derivative thermogravimetry, differential thermal analysis and differential scanning calorimetry were used to determine the thermal behavior and purity of the drugs under investigation. Thermodynamic parameters such as activation energy, enthalpy, entropy and Gibbs free energy were calculated.

Results: Thermal behavior of DAP and VAR were confirmed using by semi-empirical molecular orbital calculations. The purity values were found to be 99.97% and 99.95% for dapoxetine and vardenafil hydrochlorides, respectively. The purity of dapoxetine and vardenafil hydrochlorides is similar to that found by reported methods according to DSC data.

Conclusion: Thermal analysis justifies its application in quality control of pharmaceutical compounds due to its simplicity, sensitivity and low operational costs.

First name  
Last name  
Email address  
Security code

This Article

Google Scholar
Articles by Attia AK
Articles by Souaya ER
Articles by Soliman EA

Articles by Attia AK
Articles by Souaya ER
Articles by Soliman EA

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN