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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 08 Sep 2013
Revised: 31 Dec 2013
First published online: 07 Feb 2014

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Adv Pharm Bull. 2014;4(3):283-287 doi: 10.5681/apb.2014.041
PMID:24754013        PMCID:PMC3992965

Thermal Analysis Study of Antihypertensive Drugs Telmisartan and Cilazapril

Original Research

Refaat Ahmed Saber 1 * , Ali Kamal Attia 2, Waheed Mohamed Salem 2

1 Faculty of Technology and Development, Zagazig University, Egypt.
2 National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.



Abstract
Purpose: The aim of the present work is to study the thermal analysis of telmisartan and cilazapril. Methods: Thermogravimetry (TGA), derivative thermogravimetry (DTG) and differential thermal analysis (DTA) were used through the work to achieve the thermal analysis study of some antihypertensive drugs, telmisartan and cilazapril. Results: The results led to thermal stability data and also to the interpretation concerning the thermal decomposition. Thermogravimetry data allowed determination of the kinetic parameters such as, activation energy and frequency factor. Conclusion: The simplicity, speed and low operational costs of thermal analysis justify its application in the quality control of pharmaceutical compounds for medications.





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