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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 07 Feb 2013
Revised: 06 Apr 2013
First published online: 20 Aug 2013

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Adv Pharm Bull. 2013;3(2):367-371 doi: 10.5681/apb.2013.059
PMID:24312862        PMCID:PMC3848226

Thin Layer Chromatographic Analysis of Beta-Lactam Antibiotics

Original Research

Gabriel Hancu * , Brigitta Simon, Hajnal Kelemen, Aura Rusu, Eleonora Mircia, Arpad Gyeresi


Abstract
Purpose: The paper describes some thin layer chromatographic procedures that allow simple and rapid separation and identification of penicillins and cephalosporins from complex mixtures. Methods: Using silicagel GF254 as stationary phase and selecting different mobile phases we succeeded in the separation of the studied beta-lactamins. Our aim was not only to develop a simple, rapid and efficient method for their separation but also the optimization of the analytical conditions. Results: No system will separate all the beta-lactams, but they could be identified when supplementary information is used from color reactions and/or by using additional chromatographic systems. Conclusions: The right combination of solvent system and detection method allows the identification of the studied penicillins and cephalosporins and can be successfully used in the preliminary analysis beta-lactam antibiotics.





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