Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(0)


Article History
Submitted: 18 Sep 2012
Revised: 27 Oct 2012
First published online: 07 Feb 2013

Article Access Statistics
Abstract Page Views: 184
PDF Downloads: 126
Full Text Views: 0

Adv Pharm Bull. 2013;3(1):1-8 doi: 10.5681/apb.2013.001
PMID:24312804        PMCID:PMC3846027

Principles of Micellar Electrokinetic Capillary Chromatography Applied in Pharmaceutical Analysis

Reviews

Gabriel Hancu * , Brigitta Simon, Aura Rusu, Eleonora Mircia, Árpád Gyéresi


Abstract
Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical substances are neutral from electrophoretic point of view, consequently separations by the classic capillary zone electrophoresis; where separation is based on the differences between the own electrophoretic mobilities of the analytes; are hard to achieve. Micellar electrokinetic capillary chromatography, a hybrid method that combines chromatographic and electrophoretic separation principles, extends the applicability of capillary electrophoretic methods to neutral analytes. In micellar electrokinetic capillary chromatography, surfactants are added to the buffer solution in concentration above their critical micellar concentrations, consequently micelles are formed; micelles that undergo electrophoretic migration like any other charged particle. The separation is based on the differential partitioning of an analyte between the two-phase system: the mobile aqueous phase and micellar pseudostationary phase. The present paper aims to summarize the basic aspects regarding separation principles and practical applications of micellar electrokinetic capillary chromatography, with particular attention to those relevant in pharmaceutical analysis.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Hancu G
Articles by Simon B
Articles by Rusu A
Articles by Mircia E
Articles by Gyéresi Á

PubMed
Articles by Hancu G
Articles by Simon B
Articles by Rusu A
Articles by Mircia E
Articles by Gyéresi Á

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN