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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 19 Jul 2016
Revised: 08 Sep 2016
Accepted: 10 Sep 2016
First published online: 22 Dec 2016

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Adv Pharm Bull. 2016;6(4):495-507 doi: 10.15171/apb.2016.063

Overview of Albumin and Its Purification Methods

Mini Review

Ramin Raoufinia 1,2, Ali Mota 2, Neda Keyhanvar 1, Fatemeh Safari 1, Sara Shamekhi 1, Jalal Abdolalizadeh 3,4 *

1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Paramedical faculty, Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract
As the most frequent plasma protein, albumin constitutes more than 50% of the serum proteins in healthy individuals. It has a key role in oncotic pressure maintenance and it is known as a versatile protein carrier for transportation of various endogenous and exogenous ligands. Reduced amounts of albumin in the body will lead to different kinds of diseases such as hypovolemia and hypoproteinemia. It also has various indications in shocks, burns, cardiopulmonary bypass, acute liver failure and etc. Further applications in research consist of cell culture supplement, drug delivery carrier and protein/drug stabilizer. So, the demand for albumin increased annually worldwide. Due to different applications of albumin, many efforts have been accomplished to achieve albumin during a long period of time. In this review, an overview of serum albumin and different purification methods are summarized.





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