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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 18 Sep 2012
Revised: 07 Oct 2012
First published online: 07 Feb 2013

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Adv Pharm Bull. 2013;3(1):57-62 doi: 10.5681/apb.2013.010
PMID:24312813        PMCID:PMC3846063

Diversity of Helicobacter Pylori cagA and vacA Genes and Its Relationship with Clinical Outcomes in Azerbaijan, Iran

Original Research

Reza Ghotaslou, Morteza Milani * , Mohammad Taghi Akhi, Mohammad Reza Nahaei, Alka Hasani, Mohammad Saeid Hejazi, Mohammad Meshkini


Abstract
Purpose: The purpose of this research was to analyze cagA and vacA genotypes status in H. pylori isolates and relationship with clinical outcomes. Methods: Gastric biopsy specimens were cultured for H. pylori isolation and cagA and vacA genes were detected in these isolates. Data were collected and the results were analyzed using ?2 and Fishers exact tests by SPSS software version. 16. Results: Of the total 115 H. pylori isolates, 79 (68.7 %) were cagA positive and 82 (71.3%) of isolates contained the s1 allele which 33 (28.7%) were subtype s2. s1m2 was the most frequent vacA allelic combination in the H. pylori isolates examined (63 cases), followed by s2m2 (31 cases), s1m1 (19 cases) and s2m1 (2 case). Strains cagA positive were more frequent in peptic ulcer diseases patients than non ulcer diseases patients, as 47 (59.5%) and 32 (40.5%), while cagA negative were low, as 15 (41.7%) and 21 (58.3%), respectively. Conclusion: We found that the cagA and vacA status were not related to clinical outcomes in this area. Overall, in the present study, vacA s1/m2, cagA-positive strains were predominant irrespective of clinical outcome, but s2/m1 was rare.





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