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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 06 Oct 2012
Revised: 31 Oct 2012
First published online: 07 Feb 2013

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Adv Pharm Bull. 2013;3(1):9-11 doi: 10.5681/apb.2013.002
PMID:24312805        PMCID:PMC3846049

New Approaches in Immunotherapy of Behçet Disease

Perspective

Fatemeh Zare Shahneh, Mozhdeh Mohammadian, Zohreh Babaloo * , Behzad Baradaran


Abstract
Behçet Disease (BD) is an autoimmune disorder with recurrent ocular, vascular, central nervous system, articular, mucocutaneous, and gastrointestinal manifestations with unclear etiology and pathogenesis. The further characterization of inflammatory features of Behçet’s disease may eventually lead to development of better treatment options. Clinical and laboratory observations suggested an important role of IL-17, IL-21 and neutrophil-mediated process in the pathogenesis of BD. New therapeutic modalities target specific and nonspecific suppression of the immune system. The various non-specific immunosuppressive drugs, used either alone or in combinations, frequently fail to control inflammation or maintain remissions. Due to encouraging clinical results (i.e. Antigenic specification, prolonged survival with acceptable levels of toxicity); antibody-based drugs could be effective for the clinical management of Behçet’s disease.





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