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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 12 Apr 2013
Revised: 16 May 2013
First published online: 20 Aug 2013

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Adv Pharm Bull. 2013;3(2):443-446 doi: 10.5681/apb.2013.072
PMID:24312875        PMCID:PMC3848239

HLA-G Expression Pattern: Reliable Assessment for Pregnancy Outcome Prediction

Perspective

Elnaz Mosaferi, Jafar Majidi, Mojdeh Mohammadian, Zohreh Babaloo, Amir Monfaredan, Behzad Baradaran *


Abstract
Because mothers and fathers are more or less dissimilar at multiple HLA loci, mother considers her fetus as a semi-allograft. Mother's immune system may recognize paternal HLA as foreign antigen and may develop anti-paternal HLA antibodies and cytotoxic T lymphocyte. There are some mechanisms that modulate maternal immune responses during pregnancy, in order to make uterus an immune privileged site. This immunosuppression is believed to be mediated, at least partly, by HLA-G, non-classical class I human leukocyte antigen (HLA) molecule that is strongly expressed in cytotrophoblast and placenta. The major HLA-G function is its ability to inhibit T and B lymphocytes, NK cells and antigen-presenting cells (APC).Since HLA-G is expressed strongly at the maternofetal interface and has an essential role in immunosuppression, HLA-G polymorphism and altered expression of HLA-G seems to be associated with some complications of pregnancy, such as pre-eclampsia, recurrent misscariage and failure in IVF.This perspective discusses recent findings about HLA-G genetics, function, expression and polymorphism; and focus on HLA-G role in the etiology of recurrent miscarriage.





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