Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(4)


Article History
Submitted: 13 Feb 2013
Revised: 08 Apr 2013
First published online: 20 Aug 2013

Article Access Statistics
Abstract Page Views: 200
PDF Downloads: 136
Full Text Views: 0

Adv Pharm Bull. 2013;3(2):249-255 doi: 10.5681/apb.2013.041
PMID:24312844        PMCID:PMC3848228

Gene Therapy, Early Promises, Subsequent Problems, and Recent Breakthroughs

Original Research

Saeideh Razi Soofiyani, Behzad Baradaran * , Farzaneh Lotfipour, Tohid Kazemi, Leila Mohammadnejad


Abstract
Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to tissues for clinical applications has been discussed around half a century, but scientist’s ability to manipulate genetic material via recombinant DNA technology made this purpose to reality. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. While gene therapy initially conceived as a way to treat life-threatening disorders (inborn errors, cancers) refractory to conventional treatment, to date gene therapy is considered for many non–life-threatening conditions including those adversely influence on a patient’s quality of life. Gene therapy has made significant progress, including tangible success, although much slower than was initially predicted. Although, gene therapies still at a fairly primitive stage, it is firmly science based. There is justifiable hope that with enhanced pathobiological understanding and biotechnological improvements, gene therapy will be a standard part of clinical practice within 20 years.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Razi Soofiyani S
Articles by Baradaran B
Articles by Lotfipour F
Articles by Kazemi T
Articles by Mohammadnejad L

PubMed
Articles by Razi Soofiyani S
Articles by Baradaran B
Articles by Lotfipour F
Articles by Kazemi T
Articles by Mohammadnejad L

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN