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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 29 Oct 2015
Revised: 19 Jun 2016
Accepted: 28 Aug 2016
First published online: 25 Sep 2016

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Adv Pharm Bull. 2016;6(3):449-453 doi: 10.15171/apb.2016.058

Investigating the Apoptosis Ability of Ethylenediamine 8-Hydroxyquinolinato Palladium (II) Complex

Short Communication

Hassan Mansouri-Torshizi 1, Elham Rezaei 2, Farzaneh Kamranfar 2, Mostafa Heidari Majd 3 *

1 Chemistry Department, University of Sistan & Baluchestan, Zahedan, Iran.
2 Student Research Committee, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
3 Department of Medicinal Chemistry, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.


Department of Medicinal Chemistry, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
Email:mostafamajd@live.com


Abstract
Purpose: High solubility, low renal toxicity and apoptosis-inducing ability of palladium complexes are the reasons for their synthesis. Methods: In vitro cytotoxic study of previously synthesized [Pd(en)(8HQ)]NO3 , was carried out on breast cancer MCF-7 cell lines and prostate cancer DU145 cell lines. DNA fragmentation indicative of apoptotic was also evaluated by TUNEL assay on DU145 cell line. Results: FT-IR spectra of final complex confirmed the existence of chelating ligands. The DU145 cells unlike the MCF-7 cells, demonstrated the significant influence of the Pd (II) complex. The IC50 values of [Pd(en)(8HQ)]NO3 and cisplatin on DU145 cells were 27 and 8.3 μM, respectively. Moreover, nearly 38% apoptosis was evident in DU145 cells after treatment with [Pd(en)(8HQ)]NO3. Conclusion: [Pd(en)(8HQ)]NO3 has great potential in DNA binding and induction of apoptosis; thus it can be used in the future against prostate cancer.





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