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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 14 Apr 2014
Revised: 21 May 2014
First published online: 25 Aug 2014

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Adv Pharm Bull. 2014;4(5):459-464 doi: 10.5681/apb.2014.068
PMID:25364663        PMCID:PMC4213786

Evaluating Antiproliferative and Antioxidant Activity of Marrubium crassidens

Original Research

Sanaz Hamedeyazdan 1,2, Simin Sharifi 1,2, Hossein Nazemiyeh 2, Fatemeh Fathiazad 3 *

1 Students’ Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran.
2 Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran.
3 Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran.



Abstract
Purpose: Naturally occurring substances as novel drugs in cancer therapy, at all times, represent a challenge to science since medicinal plants are proving to be brilliant sources of new chemopreventive agents. Methods: In the present study, methanol extract from aerial parts of Marrubium crassidens was assessed for its antiproliferative activity in the breast cancer cell line MCF-7 through MTT bioassay using cell viability and cytotoxicity indices. The antioxidant property of M. crassidens extract together with its phenolic and flavonoids content were evaluated, as well. Results: According to data obtained in the study, M. crassidens exhibited antiproliferative activity with a gradual rise in cytotoxicty effect setting out on 240µg/mL concentration of the extract. Moreover, the RC50 value for antioxidant activity of the extract was determined as 40µg/mL and values for the total phenolic and flavonoids were calculated as 512.64mg gallic acid equivalent and 212.73mg quercetin equivalent per 100g of dry plant material. Conclusion: Generally, the observed antiproliferative and antioxidant properties of M. crassidens could be certified to the high amounts of phenolic and flavonoid content detected in the extract.





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