Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(2)


Article History
Submitted: 17 Nov 2012
Revised: 13 Dec 2012
First published online: 07 Feb 2013

Article Access Statistics
Abstract Page Views: 358
PDF Downloads: 159
Full Text Views: 0

Adv Pharm Bull. 2013;3(1):207-210 doi: 10.5681/apb.2013.034
PMID:24312837        PMCID:PMC3846040

Hypoglycemic Activity of Fumaria parviflora in Streptozotocin-Induced Diabetic Rats

Original Research

Fatemeh Fathiazad * , Sanaz Hamedeyazdan, Mohamad Karim Khosropanah, Arash Khaki


Abstract
Purpose: Fumaria parviflora Lam (Fumariaceae) has been used in traditional medicine in the treatment of several diseases such as diabetes. The present work was designed to evaluate the hypoglycaemic effects of methanolic extract (ME) of F. parviflora in normal and streptozotocin-induced diabetic rats. Methods: The rats used were allocated in six (I, II, III, IV, V and VI) experimental groups (n=5). Group I rats served as ‘normal control’ animals received distilled water and group II rats served as ‘diabetic control’ animals. Diabetes mellitus was induced in groups II, V and VI rats by intraperitoneal single injection of streptozotocin (STZ, 55 mg kg-1). Group V and VI rats were additionally treated with ME (150 mg kg-1 day-1 and 250 mg kg-1 day-1, i.p. respectively) 24 hour post STZ injection, for seven consecutive days. Groups III and IV rats received only ME 150 mg kg-1 day-1 and 250 mg kg-1 day-1, i.p. respectively for seven days. The levels of blood glucose were determined using a Glucometer. Results: Administration of F. parviflora extract showed a potent glucose lowering effect only on streptozotocin (STZ) induced diabetic rats below 100 mg/dl (P<0.001). However, no significant differences in the blood glucose levels were recorded between diabetic rats received 125 or 250 mg/kg of plant extracts. Conclusion: The findings of the study indicated that F. parviflora has significant hypoglycemic effect on STZ-induced diabetic rats with no effects on blood glucose levels of normal rats.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Fathiazad F
Articles by Hamedeyazdan S
Articles by Khosropanah MK
Articles by Khaki A

PubMed
Articles by Fathiazad F
Articles by Hamedeyazdan S
Articles by Khosropanah MK
Articles by Khaki A

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN