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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 01 Aug 2015
Revised: 20 Apr 2016
Accepted: 24 Apr 2016
First published online: 29 Jun 2016

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Adv Pharm Bull. 2016;6(2):195-200 doi: 10.15171/apb.2016.027

Development of Floating-Mucoadhesive Microsphere for Site Specific Release of Metronidazole

Research Article

Md. Lutful Amin 1 * , Tajnin Ahmed 1, Md. Abdul Mannan 1

1 Department of Pharmacy, Stamford University Bangladesh.

Purpose: The purpose of this study was to develop and evaluate metronidazole loadedfloating-mucoadhesive microsphere for sustained drug release at the gastric mucosa.Methods: Alginate gastroretentive microspheres containing metronidazole were preparedby ionic gelation method using sodium bicarbonate as gas forming agent, guar gum asmucoadhesive polymer, and Eudragit L100 as drug release modifier. Carbopol was used forincreasing the bead strength. The microspheres were characterized by scanning electronmicroscopy and evaluated by means of drug entrapment efficiency, in vitro buoyancy, andswelling studies. In vitro mucoadhesion and drug release studies were carried out in order toevaluate site specific sustained drug release.Results: All formulations showed 100% buoyancy in vitro for a prolonged period of time.Amount of guar gum influenced the properties of different formulations. The formulationcontaining drug and guar gum at a ratio of 1:0.5 showed the best results with 76.3% drugentrapment efficiency, 61.21% mucoadhesion, and sustained drug release. Carbopol wasfound to increase surface smoothness of the microspheres.Conclusion: Metronidazole mucoadhesive-floating microspheres can be effectively usedfor sustained drug release to the gastric mucosa in treatment of upper GIT infection.

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