Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar



Article History
Submitted: 24 Feb 2016
Revised: 30 May 2016
Accepted: 31 May 2016
First published online: 29 Jun 2016

Article Access Statistics
Abstract Page Views: 603
PDF Downloads: 262
Full Text Views: 0

Adv Pharm Bull. 2016;6(2):243-250 doi: 10.15171/apb.2016.033

Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis

Research Article

Evangelos Polymeropoulos 1 * , Pantelis Bagos 2, Maria Papadimitriou 3, Ioannis Rizos 4, Efstratios Patsouris 5, Ioannis Toumpoulis 6

1 Cardiology Department Red Cross Hospital, Athens, Greece.
2 Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece.
3 Internal Medicine Department, Laiko Hospital, Athens, Greece.
4 Cardiology Department, Attiko Hospital, Athens, Greece.
5 Department of Pathology, Medical School of the National University of Athens, Greece.
6 Cardiac Surgery Department, Attiko Hospital, Athens, Greece.



Abstract

Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for the prevention of postoperative AF in cardiac surgery.

Methods: A systematic search of PubMed, EMBASE, Google Scholar, the Cochrane Library, and clinical trial registries, was performed. 9 studies, published from August 2001 to May 2015, were included, with a total of 1,037 patients. Patients were randomized to receive vitC, or placebo.

Results: Cardiac surgery patients who received vitC as prophylaxis, had a significantly lower incidence of postoperative AF (random effects OR=0.478, 95% CI 0.340 – 0.673, P < 10-4). No significant heterogeneity was detected across the analyzed studies (I2=21.7%), and no publication bias or other small study-related bias was found.

Conclusion: Our findings suggest that VitC is effective as prophylaxis for the prevention of postoperative AF. The administration of vitC may be considered in all patients undergoing cardiac surgery.







Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Polymeropoulos E
Articles by Bagos P
Articles by Papadimitriou M
Articles by Rizos I
Articles by Patsouris E
Articles by Toumpoulis I

PubMed
Articles by Polymeropoulos E
Articles by Bagos P
Articles by Papadimitriou M
Articles by Rizos I
Articles by Patsouris E
Articles by Toumpoulis I



Share this article!

Press Manuscript Online. Powered by MAADRAYAN