APB


issn: 2228-5881
eissn: 2251-7308


Advanced Pharmaceutical Bulletin 2013;3(1):13-18. doi:10.5681/apb.2013.003
Analgesic Activity of Some 1,2,4-Triazole Heterocycles Clubbed with Pyrazole, Tetrazole, Isoxazole and Pyrimidine

Original Research

Shantaram Gajanan Khanage * , Appala Raju, Popat Baban Mohite, Ramdas Bhanudas Pandhare

Abstract
Purpose: In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated. Methods: Acetic acid induced writhing method and Hot plate method has been described to study analgesic activity of some 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine as a pharmacological active lead. Results: Thirty six different derivatives containing 1,2,4-triazole ring were subjected to study their in vivo analgesic activity. Chloro, nitro and methoxy, hydroxy and bromo substituted derivatives showed excellent analgesic activity and dimethylamino, furan and phenyl substituted derivatives showed moderate analgesic activity in both of the methods. Compounds IIIa, IIId, IIIf, IIIi, IIIj, IVa, IVb, IVd, IVf, IVh, IVj IV3a and IIj were found to be superior analgesic agents after screening by Acetic acid induced writhing method. Compounds IIIb, IIId, IIIf, IIIh, IIIj, IVa, IVb, IVd, IVf, IVh, IVi, IV3c, IV3e and IIj were showed analgesic potential after screening of Hot plate method. Conclusion: All tested compounds containing 1,2,4-triazole were found to be promising analgesic agents, for this activity pyrazole, tetrazole, isoxazole and pyrimidine leads might be supported.

Key words
Triazole, Analgesic Activity, Pyrazole, Tetrazole, Isoxazole, Pyrimidine
Article
PDF

Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks

Cite by
Google Scholar
PubMed

Google Scholar
Articles by Gajanan Khanage Shantaram
Articles by Raju Appala
Articles by Baban Mohite Popat
Articles by Bhanudas Pandhare Ramdas

PubMed
Articles by Gajanan Khanage S
Articles by Raju A
Articles by Baban Mohite P
Articles by Bhanudas Pandhare R

Copyright © 2014 by Press Manuscripts Online