Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(0)


Article History
Submitted: 06 May 2015
Revised: 21 May 2015
First published online: 19 Sep 2015

Article Access Statistics
Abstract Page Views: 413
PDF Downloads: 210
Full Text Views: 0

Adv Pharm Bull. 2015;5(3):411-417 doi: 10.15171/apb.2015.056
PMID:26504764        PMCID:PMC4616899

The Relationship between Solubility and Transdermal Absorption of Tadalafil

Original Research

Hamed Hamishehkar 1 * , Mehdi Khoshbakht 2,3, Abolghasem Jouyban 1, Saeed Ghanbarzadeh 4

1 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract

Purpose: The aim of this study was to find a relationship between drug solubility and its transdermal permeation and find the best vehicle composition to improve transdermal permeation of Tadalafil.

Methods: Pure or binary mixtures of commonly used solvents in pharmaceutical sciences including ethanol, glycerin, N-methyl pyrrolidone (NMP), polyethylene glycol (PEG) 400 and propylene glycol (PG) were evaluated for drug solubility and transdermal delivery through the exercised rat skin employing Franz diffusion cells.

Results: Tadalafil showed higher solubility in NMP compared to the other solvents. The amount of Tadalafil permeation from the pure vehicles was ranked as follow: Ethanol >glycerin >NMP>PEG 400 >PG. Furthermore, the solubility and transdermal delivery from binary mixtures of NMP and PG were higher than that obtained from pure PG, and accordingly, both increased with increasing NMP concentration in the binary solvent mixtures. The Flux values were determined as following order for Ethanol>NMP>glycerin>PG>PEG 400.

Conclusion: Generally, increase in Tadalafil solubility resulted in a decrease in its skin penetration rate and amount. However, NMP exhibited substantial drug skin penetration rate and amount accompanying with appropriate drug solvency. In conclusion, the results of this study introduced NMP as a solvent suitable for application in the formulation of topically applied drug delivery systems.







Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Hamishehkar H
Articles by Khoshbakht M
Articles by Jouyban A
Articles by Ghanbarzadeh S

PubMed
Articles by Hamishehkar H
Articles by Khoshbakht M
Articles by Jouyban A
Articles by Ghanbarzadeh S

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN