Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(0)


Article History
Submitted: 17 Sep 2014
Revised: 05 Oct 2014
First published online: 31 Oct 2014

Article Access Statistics
Abstract Page Views: 350
PDF Downloads: 208
Full Text Views: 0

Adv Pharm Bull. 2014;4(6):569-575 doi: 10.5681/apb.2014.084
PMID:25671191        PMCID:PMC4312407

Formulation of Nanoliposomal Vitamin D3 for Potential Application in Beverage Fortification

Original Research

Maryam Mohammadi 1,2, Babak Ghanbarzadeh 2, Hamed Hamishehkar 3 *

1 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract
Purpose: Vitamin D, a liposoluble vitamin has many benefits on health. Encapsulation of bioactives in lipid-based carrier systems like nanoliposomes preserves their native properties against oxidation over time along with providing its stable aqueous dispersion. Methods: In the current study, vitamin D3 nanoliposomes were prepared using thin-film hydration­- sonication method and fully characterized by different instrumental techniques. Results: According to FTIR and DSC results, no interaction was observed between encapsulated nutraceutical and liposome constituents. The particle size and size distribution (Span value) were calculated 82–90 nm and 0.70–0.85, respectively. TEM analysis showed nano sized globular and bilayer vesicles. In all formations, the encapsulation efficiency of vitamin D3 was calculated more than 93%.­ Addition of cholesterol to lecithin bilayer increased the negative zeta potential from -29 to -43mV. Conclusion: The results of this study concluded that the liposomal nanoparticles may be introduced as a suitable carrier for fortification of beverages with vitamin D3.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Mohammadi M
Articles by Ghanbarzadeh B
Articles by Hamishehkar H

PubMed
Articles by Mohammadi M
Articles by Ghanbarzadeh B
Articles by Hamishehkar H

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN